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Directed In Vitro Myogenesis of Human Embryonic Stem Cells and Their In Vivo Engraftment

19 Aug 2013

Abstract excerpt

Development of human embryonic stem cell (hESC)-based therapy requires derivation of in vitro expandable cell populations that can readily differentiate to specified cell types and engraft upon transplantation. Here, we report that hESCs can differentiate into skeletal muscle cells without genetic manipulation. This is achieved through the isolation of cells expressing a mesodermal marker, platelet-derived growth...

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PMID: 23977197
DOI: 10.1371/journal.pone.0072023

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