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Neutralizing antibody-independent immunity to SARS-CoV-2 in Syrian hamsters and human ACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

2021-11-08

Abstract excerpt

<title>Abstract</title> <p>The nucleocapsid (N) and the receptor binding domain (RBD) of the Spike (S) proteins elicit robust antibody and T cell responses either in vaccinated or COVID-19 convalescent individuals. We generated a chimeric protein that comprises the sequences of RBD from S and N antigens (SpiN). SpiN was highly immunogenic and elicited a strong IFNγ response from T cells and high levels of antibod...

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Literature Corpus work
5d05f2b1-43e1-5f55-a79c-a75a2f8cd227
DOI
10.21203/rs.3.rs-1040853/v1
Open publication

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Neutralizing antibody-independent immunity to SARS-CoV-2 in Syrian hamsters and human ACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion proteinDOI 10.21203/rs.3.rs-1040853/v1
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