Article

Senolytic targeting of CAF-induced KRT17 <sup>+</sup> colon cancer cells inhibits metastatic invasion

2026-03-05

Abstract excerpt

Metastasis remains the leading cause of cancer mortality, yet effective strategies to eliminate metastasis-initiating cells are lacking. Here, we dissected intratumoral heterogeneity in colon cancer using single-cell analyses and identified a KRT17 + slow-cycling cancer cell population that exhibits features of metastasis-initiating cells ( L1CAM ) and senescent-like cells ( CDKN2A, BCL2L1 ). Spatial transcrip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5cf7ebe4-7805-5452-a481-20f6f9e14ba7
DOI: 10.64898/2026.03.03.708913

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Senolytic targeting of CAF-induced KRT17 <sup>+</sup> colon cancer cells inhibits metastatic invasionDOI 10.64898/2026.03.03.708913Read

The SW480 cell line as a model of resident and migrating colon cancer stem cellsSemantic proximity Read

Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Drivers in Serrated Pathway-Driven Colorectal Cancer ProgressionSemantic proximity Read

Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancerSemantic proximity Read

An oncogenic phenoscape of colonic stem cell polarizationSemantic proximity Read

Identification of a unique subpopulation of mucosal fibroblasts in colorectal cancer with tumor-restraining characteristicsSemantic proximity Read

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMTSemantic proximity Read

COL10A1+ fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevanceSemantic proximity Read

TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoidsSemantic proximity Read

Fibroblasts in Orchestrating Colorectal Tumorigenesis and ProgressionSemantic proximity Read

THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancerSemantic proximity Read

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression.Semantic proximity Read

Identification of a Unique Subpopulation of Mucosal Fibroblasts in Colorectal Cancer with Tumor- Restraining CharacteristicsSemantic proximity Read