Article

Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regeneration

2025-04-21

Abstract excerpt

<h4>Background</h4> The anthracycline doxorubicin (Dox) is a widely used genotoxic chemotherapeutic drug with known dose-limiting cardiotoxic effects. How Dox-induced damage either to cardiomyocytes or to cardiac stem cells, which may compromise cardiac regeneration, contributes to cardiotoxicity remains poorly understood. <h4>Methods</h4> Here we used a human induced pluripotent stem cell (iPSC)-based model sys...

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Literature Corpus work: 5ceb7752-26cf-5669-b7dd-f87cf409e908
DOI: 10.1101/2025.04.18.649376

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Preconditioning of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming in iPSC-derived cardiomyocytes linked to mitochondrial dysfunction and impaired cardiac regenerationDOI 10.1101/2025.04.18.649376Read

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