Article

RAS mutations that have a major impact on current cancer genomic medicine

2022-09-16

Abstract excerpt

The status of rat sarcoma viral oncogene homolog (RAS) proteins is a negative predictive biomarker for anti-epidermal growth factor receptor (EGFR) therapy in metastatic colon cancer. In the phase 2 CHRONOS trial, patients with mutant gene(s) are ineligible for anti-EGFR therapy. However, our studies revealed that splicing caused by the RAS mutations, which were considered oncogenic, generates unfunctional RAS fam...

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Literature Corpus work: 5c91fbc8-ee2d-5ed9-b09d-cffdab07c635
DOI: 10.32388/jwnw97

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