Article

A structural analysis of amyloid polymorphism in disease: clues for selective vulnerability?

2021-03-01

Abstract excerpt

The increasing amount of amyloid structures offers an opportunity to investigate the general principles determining amyloid stability and polymorphism in disease. We find that amyloid stability is dominated by about 30% of residues localized in few segments interspersed with regions that are often structurally frustrated in the cross-β conformation. These stable segments correspond to known aggregation-nucleating...

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Literature Corpus work: 5c78bf7f-9fbb-5ae4-8d07-3f880941ecff
DOI: 10.1101/2021.03.01.433317

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