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DNA-Damage-Repair Gene Alterations in Genitourinary Malignancies

1 Jan 2022

Abstract excerpt

BACKGROUND: High-fidelity repair of DNA damage repair (DDR) (either single-strand- [SSBs] or double-strand breaks [DSBs]) is necessary for maintaining genomic integrity and cell survival. DDR alterations are commonly found in genitourinary malignancies involving either DSB repair by the homologous recombination (HR) repair (HRR) system (BRCA1/2 pathway) or the SSB repair through the poly (ADP-ribose) polymerase...

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PMID: 35944490
DOI: 10.1159/000526415

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