Article

Exercise Engages Coordinated Neuron–Glia Signaling to Shape Spinal Cord Plasticity

2025-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Physical activity induces systemic benefits for brain and muscle function, but how the healthy spinal cord adapts to exercise remains largely unknown. Here, we combine bulk proteomics, single-nucleus RNA sequencing, and cellular communication inference to map exercise- induced molecular adaptations in the mouse lumbar spinal cord. Endurance training elicited robust baseline remodeling, dominated...

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Literature Corpus work: 5c5ab4f8-d1eb-534d-9826-c962d59231d7
DOI: 10.64898/2025.12.11.693787

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