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Article

Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS

1 Apr 2009

Abstract excerpt

The transcriptional adaptive response of motoneurons and muscles to voluntary exercise has been investigated by using laser capture microdissection and microarray analysis. Our results show that motoneurons respond to physical activity by activating a complex transcriptional plan, with changes involved in neurotrophic factor signalling, electrophysiological changes and synaptic reorganization. Gastrocnemius...

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PMID: 19344372
DOI: 10.1111/j.1471-4159.2009.06080.x

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