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DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium

9 Dec 2021

Abstract excerpt

The pathophysiological mechanisms of postoperative delirium (POD) are still not clear, and no reliable biomarker is available to differentiate those with and without POD. Pre- and post-surgery blood from epilepsy subjects undergoing neurosurgery were collected. DNA methylation (DNAm) levels of the TNF gene, IL1B gene, and IL6 gene by the Illumina EPIC array method, and DNAm levels of the TNF gene by...

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PMID: 34887385
DOI: 10.1038/s41398-021-01752-6

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