Article

The Effect of Dichotomization of Skewed Adjustment Covariates in the Analysis of Clinical Trials

2022-08-16

Abstract excerpt

<title>Abstract</title><p>Baseline imbalance in covariates associated with the primary outcome in clinical trials leads to bias in the reporting of results. Standard practice is to mitigate that bias by stratifying by those covariates in the randomization. Additionally, for continuously valued outcome variables, precision of estimates can be (and should be) improved by controlling for those covariates in analysis....

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Literature Corpus work: 5b85a053-df5e-5d1f-bec0-71be86383f12
DOI: 10.21203/rs.3.rs-1919644/v1

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