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Prognostic significance of a signature based on senescence-related genes in colorectal cancer

25 Apr 2024

Abstract excerpt

Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis. Cellular senescence, a DNA damage-induced cellular stress response, is characterized by cell cycle arrest, the expression of an inflammatory senescence-associated secretory phenotype, and alterations in extracellular matrix metabolism. It is widely...

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PMID: 38658505
DOI: 10.1007/s11357-024-01164-6

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