Article

The effect of HNF4α knockout in beta cells is age and gender dependent

2024-12-17

Abstract excerpt

HNF4α is important for beta cells’ ability to adequately secrete insulin in response to glucose concentration and endoplasmic reticulum (ER) homeostasis. In humans, HNF4α mutation is responsible for Diabetes mellitus subtype MODY1, which has age determined onset. In addition, in other types of DM, there are evidences that gender can influence beta cell dysfunction, with possible involvement of ER stress pathways....

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Literature Corpus work: 5b144db4-673d-5523-b350-e208c998a5c0
DOI: 10.1101/2024.12.16.628662

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