Article

Repeat expansions in Parkinson’s disease and parkinsonism across ancestries: insights from a global genetic cohort

2026-06-22

Abstract excerpt

Expanded short tandem repeats contribute to a broad spectrum of neurodegenerative diseases, yet their roles in Parkinson’s disease (PD) and parkinsonism remain incompletely characterized, especially across diverse ancestries. We analyzed short-read whole-genome (WGS) and clinical exome sequencing (CES) data from 38,365 individuals (28,861 WGS; 9,504 CES), encompassing 23,242 patients with PD, 4,729 patients with a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5abbccfa-bb88-5967-9dac-c9f8e6f4075c
DOI: 10.64898/2026.06.12.26354932

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repeat expansions in Parkinson’s disease and parkinsonism across ancestries: insights from a global genetic cohortDOI 10.64898/2026.06.12.26354932Read

Association of Non-Coding Repeat Expansions with Parkinson's Disease Risk: Evidence from a UK Biobank-Based Whole-Genome Sequencing Study.Semantic proximity Read

Parkinson's disease genetics across diverse ancestries: an observational genetic study of causal and risk variants with translational implications.Semantic proximity Read

Genome-wide analysis of Structural Variants in Parkinson’s Disease using Short-Read Sequencing dataSemantic proximity Read

Global Parkinson’s Genetics Program (GP2) Monogenic Network Protocol: Elucidating causative gene variants in hereditary Parkinson’s diseaseSemantic proximity Read

Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.Semantic proximity Read

Genome-wide contribution of common Short-Tandem Repeats to Parkinson’s Disease genetic riskSemantic proximity Read

Large-scale genetic characterization of Parkinson's disease in the African and African admixed populations.Semantic proximity Read

The Global Landscape of Genetic Variation in Parkinson’s disease: Multi-Ancestry Insights into Established Disease Genes and their Translational RelevanceSemantic proximity Read

Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s diseaseSemantic proximity Read

Large-scale rare variant burden testing in Parkinson's disease.Semantic proximity Read

Novel Parkinson’s Disease Genetic Risk Factors Within and Across European PopulationsSemantic proximity Read

Short tandem repeat expansions in patients with neurodegenerative dementia.Semantic proximity Read