Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Non-Coding Repeat Expansions with Parkinson's Disease Risk: Evidence from a UK Biobank-Based Whole-Genome Sequencing Study.

Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2026

Hu Zhen, Yan Qin-Qin, Wan Jing-Jin, Fan Yu, Liu Jun

Abstract excerpt

BACKGROUND: Nucleotide repeat expansions are a potential factor in Parkinson's disease (PD) risk, but previous studies were inconsistent. We investigated 14 non-coding repeat expansion genes (C9ORF72, FMR1, AFF2, ATXN8OS, ATXN10, CNBP, CSTB, DMPK, FXN, NOP56, NOTCH2NLC, PPP2R2B, RFC1, and TCF4) in a large cohort. METHODS: We used whole-genome sequencing (WGS) data from the United Kingdom (UK) Biobank, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to C9orf72 Protein

Share to DNA Repeat Expansion

Share to Parkinson Disease

Share to UK Biobank

Share to United Kingdom

Share to Whole Genome Sequencing

Source

Identifiers

PMID: 41074692
DOI: 10.1002/mds.70081

Genes

C9ORF72
FMR1
AFF2
ATXN10
CNBP
CSTB
DMPK
FXN
NOP56
NOTCH2NLC
RFC1
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Non-Coding Repeat Expansions with Parkinson's Disease Risk: Evidence from a UK Biobank-Based Whole-Genome Sequencing Study.PMID 41074692Read ↗

Repeat expansions in Parkinson’s disease and parkinsonism across ancestries: insights from a global genetic cohortSemantic proximity Read ↗

Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s diseaseSemantic proximity Read ↗

Short tandem repeat expansions in patients with neurodegenerative dementia.Semantic proximity Read ↗

C9orf72 intermediate expansions of 24–30 repeats are associated with ALSSemantic proximity Read ↗

Long-read sequencing identifies <i>FGF14</i> repeat expansions in Parkinson’s diseaseSemantic proximity Read ↗

Genome-wide contribution of common short-tandem repeats to Parkinson's disease genetic risk.Semantic proximity Read ↗

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource.Semantic proximity Read ↗

Low Prevalence of NOTCH2NLC GGC Repeat Expansion in White Patients with Movement DisordersSemantic proximity Read ↗

A Complex FGF14 (TTC)/(TGC) Repeat Expansion in Parkinson's Disease.Semantic proximity Read ↗

Large-scale rare variant burden testing in Parkinson's disease.Semantic proximity Read ↗

Population-scale repeat expansions elucidate disease risk and brain atrophy.Semantic proximity Read ↗

Expanded CAG Repeats in ATXN1, ATXN2, ATXN3, and HTT in the 1000 Genomes Project.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.