Article

Inhibition of tRNA Synthetases Induces Persistence in <i>Chlamydia</i>

2019-09-05

Abstract excerpt

Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections, and C. pneumoniae causes community-acquired respiratory infections. In vivo , the host immune system will release interferon-gamma (IFNγ) to combat infection. IFNγ activates human cells to produce the tryptophan (trp) catabolizing enzyme, IDO. Consequently, there is a reduction in cytosolic trp in IFNγ-activated host cells....

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Literature Corpus work: 5a9b8ca9-1e0f-5b91-a570-beae1d846c66
DOI: 10.1101/759084

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