Article
Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.
Cell reports - 16 May 2017
Weber Mary M, Lam Jennifer L, Dooley Cheryl A, Noriea Nicholas F, Hansen Bryan T, Hoyt Forrest H, Carmody Aaron B, Sturdevant Gail L, Hackstadt Ted
Abstract excerpt
Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic factors. Using recently developed genetic tools, we show that three inclusion membrane proteins...
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