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The gut microbiome and cancer response to immune checkpoint inhibitors

2 Feb 2025

Abstract excerpt

Immune checkpoint inhibitors (ICIs) are widely used for cancer immunotherapy, yet only a fraction of patients respond. Remarkably, gut bacteria impact the efficacy of ICIs in fighting tumors outside of the gut. Certain strains of commensal gut bacteria promote antitumor responses to ICIs in a variety of preclinical mouse tumor models. Patients with cancer who respond to ICIs have a different microbiome compared...

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PMID: 39895632
DOI: 10.1172/jci184321

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