Article

Pain-regulation circuitry as a predictor of chronic pain phenotypes

2026-01-21

Abstract excerpt

Chronic pain involves sensory, emotional, and functional disruption, yet diagnostic labels rarely capture this variability, limiting individualized care. Multidimensional models, such as fear-avoidance and predictive coding, suggest that high emotional burden may disrupt expectation-based pain modulation and midbrain pain regulatory pathways, particularly within the periaqueductal gray (PAG). We tested whether chr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a938290-d77e-5735-bc97-f315c711f2a1
DOI: 10.64898/2026.01.20.699535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pain-regulation circuitry as a predictor of chronic pain phenotypesDOI 10.64898/2026.01.20.699535Read

Brain mechanisms of pain anticipation in chronic low back pain: Insights into phenotypical responses to mind-body therapy.Semantic proximity Read

A Data-Driven Biopsychosocial Framework Determining the Spreading of Chronic PainSemantic proximity Read

Linking Data-Driven Symptom Dimensions to Resting-State EEG Biomarker Candidates in Chronic PainSemantic proximity Read

Pain-related fear – Dissociable neural sources of different fear constructsSemantic proximity Read

Biological markers of brain network connectivity and pain sensitivity distinguish low coping from high coping Veterans with persistent post-traumatic headacheSemantic proximity Read

Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individualsSemantic proximity Read

Biobehavioral phenotypes of chronic low back pain: Psychosocial subgroup identification using latent profile analysis.Semantic proximity Read

The Anxiety and Pain of Fibromyalgia Patients during the COVID-19 PandemicSemantic proximity Read

Psychophysical pain encoding in the cingulate cortex predicts responsiveness of electrical stimulationSemantic proximity Read

Psychophysiological responses to pain identify reproducible human clusters.Semantic proximity Read

Experimental Pain Phenotypes in Individuals With Symptomatic Knee Osteoarthritis: A Neural Network-Based Clustering Approach.Semantic proximity Read

Disease Phenotypes in Refractory Musculoskeletal Pain Syndromes Identified by Unsupervised Machine LearningSemantic proximity Read