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Article

Brain mechanisms of pain anticipation in chronic low back pain: Insights into phenotypical responses to mind-body therapy.

The journal of pain - 1 Apr 2026

Strigo Irina A, Torrisi Salvatore, Guerra Sergio Garcia, Alter Benedict J, Lotz Jeffrey C, Mehling Wolf E, Simmons Alan N

Abstract excerpt

Pain perception and emotional processing share common predictive mechanisms influenced by anticipation, expectation, and uncertainty. This study identifies distinct neural phenotypes of pain anticipation in chronic low back pain(cLBP) and examines their clinical and physiological correlates. In 43 cLBP patients, we acquired task-based functional MRI during certain(high/low) and uncertain pain anticipation,...

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Identifiers

PMID: 41690396
DOI: 10.1016/j.jpain.2026.106212
PMCID: PMC13528188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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