Article
Psychophysiological responses to pain identify reproducible human clusters.
Pain - 1 Nov 2013
Farmer Adam D, Coen Steven J, Kano Michiko, Paine Peter A, Shwahdi Mustafa, Jafari Jafar, Kishor Jessin, Worthen Sian F, Rossiter Holly E, Kumari Veena, Williams Steven C R, Brammer Michael, Giampietro Vincent P, Droney Joanne, Riley Julia, Furlong Paul L, Knowles Charles H, Lightman Stafford L, Aziz Qasim
Abstract excerpt
Pain is a ubiquitous yet highly variable experience. The psychophysiological and genetic factors responsible for this variability remain unresolved. We hypothesised the existence of distinct human pain clusters (PCs) composed of distinct psychophysiological and genetic profiles coupled with differences in the perception and the brain processing of pain. We studied 120 healthy subjects in whom the baseline...
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