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Article

Biobehavioral phenotypes of chronic low back pain: Psychosocial subgroup identification using latent profile analysis.

Pain medicine (Malden, Mass.) - 1 Jan 2026

Gholi Zadeh Kharrat Fatemeh, Amar Kumar Prakruthi, Mehling Wolf, Strigo Irina, Lotz Jeffrey, Peterson Thomas A

Abstract excerpt

OBJECTIVE: This study identifies distinct biobehavioral phenotypes among patients with chronic low back pain (cLBP) using Latent Profile Analysis (LPA). METHODS: These phenotypes were derived from baseline data from two cohorts within the NIH HEAL BACPAC consortium: BACKHOME, a large nationwide e-cohort (N = 3025) utilized for model training, and COMEBACK as external test set, a deep phenotyping cohort (N = 450)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 40711854
DOI: 10.1093/pm/pnaf095
PMCID: PMC12419233

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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