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IL-21 Rescues The Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice

2021-02-15

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold> Mutations in human DOCK8 cause a combined immunodeficiency syndrome characterized by allergic diseases such as asthma and food allergy. However, the underlying mechanism is unclear. Regulatory B (Breg) cells that produce IL-10 exert potent immunosuppressive functions in patients with allergic and autoimmune disorders. DOCK8-deficient B cells have been revealed dimin...

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Literature Corpus work
5a5eab30-4c21-5e56-9927-c7c35b770b76
DOI
10.21203/rs.3.rs-169340/v1
Open publication

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IL-21 Rescues The Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient MiceDOI 10.21203/rs.3.rs-169340/v1
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