Influence of pH on the Cytotoxic Activity of Organic Acids against Breast Cancer Cells

Abstract excerpt

<title>Abstract</title> <p>Cancer is among the leading causes of death, and breast cancer is the most common cancer in women worldwide. Cancer cells including breast cancer cells generate a reversed pH gradient. Cancer cells have lower extracellular pH (pHe) of ~6.7 - 7.1 and higher intracellular pH (pHi) of 7.4, while normal cells have pHe of 7.4 and lower pHi of 7.2. Exogenous pH changes can modulate the cell g...

Topics

Open a Topic to create a Post that cites this publication.

• Cancer, Hypoxia, and Metabolism
• Diet and metabolism studies
• Homeostasis
• Hydrogen-Ion Concentration
• Ion Transport and Channel Regulation
• Metabolomics and Mass Spectrometry Studies
• Neoplasms
• Phenotype

Identifiers and source

Literature Corpus work

59bd6f3f-6caf-5ee9-ba8e-bc1a99417a4a

DOI

10.21203/rs.3.rs-4409558/v1