Measurement of Bone Marrow Tumour Burden and Minimal Residual Disease in Waldenstrom’s Macroglobulinemia through Cell-free Whole Genome Sequencing

Abstract excerpt

<h4>Purpose</h4> We assessed the utility of blood cell-free DNA (cfDNA) whole genome sequencing (cfWGS) for minimal residual disease (MRD) monitoring in Waldenstrom’s macroglobulinemia (WM) by comparing this to 1) targeted panel sequencing of 27 genes of interest in WM and targeted capture of immunoglobulin gene rearrangements in blood and bone marrow 2) Multiplex-PCR of immunoglobulin loci followed by Illumina se...

Topics

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• Chronic Lymphocytic Leukemia Research
• DNA Copy Number Variations
• Genomics
• Mutation
• Myeloid Differentiation Factor 88
• Pathology, Molecular
• Receptors, CXCR4
• Waldenstrom Macroglobulinemia

Identifiers and source

Literature Corpus work

599b303f-ecfe-575f-b06b-efbfe90ad81a

DOI

10.1101/2025.05.11.25326925