Article

Distinct immune and genomic signatures predict resistance to ibrutinib therapy in Waldenström macroglobulinemia

2026-01-23

Abstract excerpt

<title>Abstract</title> <p> Despite recent advances in treatment strategies of Waldenström macroglobulinemia (WM) patients, the disease remains incurable. While several genomic features predict poor outcomes with ibrutinib, the contribution of immune dysfunction to tumor behavior remains unclear. Single-cell RNA sequencing on longitudinal bone marrows from 37 Waldenström macroglobulinemia patients before and aft...

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Literature Corpus work: 738697d2-5bed-5780-a273-4dd8844ef904
DOI: 10.21203/rs.3.rs-8594385/v1

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