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Article

Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance.

eLife - 26 Jul 2023

Masson Stewart W C, Madsen Søren, Cooke Kristen C, Potter Meg, Vegas Alexis Diaz, Carroll Luke, Thillainadesan Senthil, Cutler Harry B, Walder Ken R, Cooney Gregory J, Morahan Grant, Stöckli Jacqueline, James David E

Abstract excerpt

Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. 'Diversity Outbred in Australia (DOz)' is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance to explore skeletal muscle's contribution to whole-body insulin action through metabolic phenotyping and skeletal...

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Identifiers

PMID: 37494090
DOI: 10.7554/eLife.86961
PMCID: PMC10371229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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