Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic gain-of-function mutation in TLR7 causes early-onset systemic lupus erythematosus

6 Feb 2025

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to interferon and immune responses
Share to Systemic Lupus Erythematosus Research

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39919974
DOI: 10.1016/j.ard.2025.01.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic gain-of-function mutation in TLR7 causes early-onset systemic lupus erythematosusPMID 39919974Read ↗

Interface Gain-of-Function Mutations in TLR7 Cause Systemic and Neuro-inflammatory Disease.Semantic proximity Read ↗

Monogenic autoimmunity caused by TLR7 gain-of-functionSemantic proximity Read ↗

A case of autoimmune hemolytic anemia with acquired functional mutation of the TLR7.Semantic proximity Read ↗

TLR8/TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins.Semantic proximity Read ↗

Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patientsSemantic proximity Read ↗

For whom the B cells toll.Semantic proximity Read ↗

A novel <i>UNC93B1</i> gain-of-function mutation leads to TLR7 and TLR8 hyperactivation and systemic lupus erythematosusSemantic proximity Read ↗

TLR7 Variants Enhance Responsiveness and Broaden RNA Specificity To Drive Human LupusSemantic proximity Read ↗

From Rare to Common: Genetic Insights into TLR7 Variants in a Multicentric Spanish Study on COVID-19 Severity.Semantic proximity Read ↗

The genomic architecture of NLRP7 is Alu rich and predisposes to disease-associated large deletionsSemantic proximity Read ↗

Endosome dysfunction leads to gain-of-function TLR7 and human lupusSemantic proximity Read ↗

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus ErythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.