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Human placental trophoblasts support sustained <i>Treponema pallidum</i> replication and reveal new candidate host pathways implicated in congenital syphilis

2026-05-10

Abstract excerpt

Congenital syphilis is a leading cause of preventable stillbirth, yet the mechanisms that enable Treponema pallidum subsp. pallidum, the etiological agent of syphilis, to traverse and persist within the human placenta are virtually unknown. This knowledge gap reflects, in part, the fastidious nature of T. pallidum , which has historically only been propagated in rabbit epithelial cells. Here, we demonstrate tha...

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Literature Corpus work
87d3320e-08e3-504a-9042-81489a67a0f2
DOI
10.64898/2026.05.10.724106
Open publication

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Human placental trophoblasts support sustained <i>Treponema pallidum</i> replication and reveal new candidate host pathways implicated in congenital syphilisDOI 10.64898/2026.05.10.724106
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