Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development.

Tissue engineering. Part A - 1 Jun 2016

Balasubramanian Swarnalatha, Packard John A, Leach Jennie B, Powell Elizabeth M

Abstract excerpt

Astrocytes are critical for coordinating normal brain function by regulating brain metabolic homeostasis, synaptogenesis and neurotransmission, and blood-brain barrier permeability and maintenance. Dysregulation of normal astrocyte ontogeny contributes to neurodevelopmental and neurodegenerative disorders, epilepsies, and adverse responses to injury. To achieve these multiple essential roles, astrocyte phenotypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Cell Proliferation

Share to Cell Shape

Share to Cellular Microenvironment

Share to Glial Fibrillary Acidic Protein

Share to Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 27193766
DOI: 10.1089/ten.TEA.2016.0103
PMCID: PMC4913501

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development.PMID 27193766Read ↗

Diversity of astrocyte functions and phenotypes in neural circuits.Semantic proximity Read ↗

Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrixSemantic proximity Read ↗

“Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity”Semantic proximity Read ↗

A novel approach to increase glial cell populations in brain microphysiological systemsSemantic proximity Read ↗

An update on human astrocytes and their role in development and diseaseSemantic proximity Read ↗

Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective.Semantic proximity Read ↗

Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration.Semantic proximity Read ↗

Diverse But Unique Astrocytic Phenotypes During Embryonic Stem Cell Differentiation, Culturing and DevelopmentSemantic proximity Read ↗

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic SignaturesSemantic proximity Read ↗

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and agingSemantic proximity Read ↗

Astrocytes Grown in Alvetex(®) Three Dimensional Scaffolds Retain a Non-reactive Phenotype.Semantic proximity Read ↗

Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses NeurogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.