Article

Implementation of NGS Analysis for the Detection of RET Rearrangements in Thyroid Cancer Patients. An Inter-Laboratory Validation of the Method

2025-03-25

Abstract excerpt

<h4>Background: </h4> /Objectives: The clinical use of molecular biomarkers in thyroid cancer management requires standardized technical and analytical criteria, especially for gene fusion detection. Accurate identification of patients suitable for RET-selective inhibitors, a new treatment for advanced thyroid cancer, depends on effective molecular testing. This study aimed to validate molecular alterations in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58faf316-0301-5f41-80c4-e6aaf4b22a14
DOI: 10.20944/preprints202503.1863.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Implementation of NGS Analysis for the Detection of RET Rearrangements in Thyroid Cancer Patients. An Inter-Laboratory Validation of the MethodDOI 10.20944/preprints202503.1863.v1Read

A Performance Comparison of Commonly Used Assays to Detect RET FusionsSemantic proximity Read

Consensus Recommendations to Optimize the Detection and Reporting of NTRK Gene Fusions by RNA-Based Next-Generation SequencingSemantic proximity Read

RET Gene Fusions in Malignancies of the Thyroid and Other TissuesSemantic proximity Read

Clinical Application of Next-Generation Sequencing in Advanced Thyroid Cancers.Semantic proximity Read

Molecular testing for oncogenic gene mutations in thyroid lesions: a case-control validation study in 413 postsurgical specimens.Semantic proximity Read

Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel.Semantic proximity Read

Development and Analytical Validation of an Expanded Mutation Detection Panel for Next-Generation Sequencing of Thyroid Nodule Aspirates.Semantic proximity Read

High success rate of first proficiency testing for RET fusions and RET mutations in lung and thyroid cancer samples by various methods.Semantic proximity Read

Clinicopathological analysis of thyroid carcinomas with the RET and NTRK fusion genes: characterization for genetic analysisSemantic proximity Read

Diagnosis and Management of Tropomyosin Receptor Kinase Fusion-Positive Thyroid CarcinomasSemantic proximity Read

Targeted Next-Generation Sequencing Panel (ThyroSeq) for Detection of Mutations in Thyroid CancerSemantic proximity Read

NTRK Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on PrognosisSemantic proximity Read