Article

Homozygous RRM2 Variant Might Lead to Early Embryo Developmental Arrest: A Case Report

2020-07-30

Abstract excerpt

<h4>Background: </h4> Early embryonic developmental stagnation is one of the reasons that affect the outcome of in vitro fertilization-embryo transfer, leading to the depletion of available embryos or failure after transplantation. It has been shown that defects in the ribonucleotide-reductase lead to cell cycle arrest, developmental delay, and high mutation rates. Case presentation Two female patients, who were s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5290ea41-4a43-53d6-a235-e88ee3272373
DOI: 10.21203/rs.3.rs-50066/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Homozygous RRM2 Variant Might Lead to Early Embryo Developmental Arrest: A Case ReportDOI 10.21203/rs.3.rs-50066/v1Read

Genetic variants underlying developmental arrests in human preimplantation embryosSemantic proximity Read

Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrestSemantic proximity Read

A novel variant in TLE6 is associated with embryonic developmental arrest (EDA) in familial female infertility.Semantic proximity Read

A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.Semantic proximity Read

Mutations in NLRP2 and NLRP5 cause female infertility characterised by early embryonic arrestSemantic proximity Read

RGS12 as a Novel Maternal-Effect Gene Causes Arrest at the Pronuclear Stage of Human ZygoteSemantic proximity Read

Homozygous mutations in REC114 cause female infertility characterised by multiple pronuclei formation and early embryonic arrest.Semantic proximity Read

Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like stateSemantic proximity Read

Embryonic arrest: causes and implicationsSemantic proximity Read

SRRM2 splicing factor modulates cell fate in early developmentSemantic proximity Read

Transcriptome analysis of human preimplantation embryo reveals expressed waves associated with blastulation failure based on embryonic grade and ageSemantic proximity Read

A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.Semantic proximity Read