Article

Haplotype analysis at HTT locus in Huntington’s disease patients from India

2023-10-10

Abstract excerpt

<title>Abstract</title> <p>Huntington's disease (HD) is caused by an increase in the number of CAG triplet repeats in exon 1 of the Huntingtin (<italic>HTT</italic>) gene. Expansions that contain more than 39 repeats predispose to disease. Some specific genetic elements (SNPs), and the haplotypes they create (haplogroups A, B, and C), located at the <italic>HTT</italic> locus seem to impact CAG repeat instability...

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Literature Corpus work: 58a9bdc8-276e-503f-9969-eca66f2e7944
DOI: 10.21203/rs.3.rs-3365710/v1

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