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Article

Distribution of the HTT Gene A1 and A2 Haplotypes Worldwide: A Systematic Review.

Clinical medicine & research - 1 Dec 2020

Apolinário Thays Andrade, Rodrigues Dionatan Costa, Lemos Mayra Braga, Antão Paiva Carmen Lúcia, Agostinho Luciana Andrade

Abstract excerpt

BACKGROUND: Huntington's disease (HD)(MIM:143100) is an severe autosomal dominant neurodegenerative disease caused by the dynamic expansion of CAG trinucleotides (> 35) in the HTT gene [Genomic Coordinates- (GRCh38):4:3,074,680-3,243,959]. OBJECTIVES: The aim of this systematic review was to investigate the reported associations between the frequencies of the A1 and A2 haplotypes in HD-affected and non-affected...

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Identifiers

PMID: 32878904
DOI: 10.3121/cmr.2020.1523
PMCID: PMC7735449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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