Article

Allelic Diversity, de novo CAG Expansions, and Intergenerational Instability at the HTT Locus in a clinical sample of Huntington’s Disease from India

2025-03-04

Abstract excerpt

<h4>BACKGROUND</h4> Huntington’s disease (HD) is an inherited, neurodegenerative disorder, caused by the expansion of an unstable CAG repeat sequence in the HTT gene. The prevalence of HD, allelic diversity, rate of novel expansions, and the clinical correlates, vary across populations. <h4>OBJECTIVE</h4> We aimed to analyze the diversity of alleles, and their clinical correlates; and describe the mode of inherita...

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Literature Corpus work: 041b09e9-2287-5c09-870e-112a78d411a5
DOI: 10.1101/2025.03.03.21260193

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