Article

Uncovering the Genetic and Molecular Features of Huntington's Disease in Northern Colombia

2023-07-11

Abstract excerpt

<h4>Background: </h4> The second world's most extensive cluster of patients affected with Huntington’s disease (HD), a genetic disorder caused by a CAG trinucleotide expansion in the huntingtin ( HTT) gene, inhabits Juan de Acosta, a city located on the Caribbean coast of Colombia. This group represents the second most extensive pedigree clustering HD in the world. Methods We included 291 descendants of families...

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Literature Corpus work: 60f15e2c-b84f-53ef-bd98-df911362b2f8
DOI: 10.21203/rs.3.rs-3139939/v1

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