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Article

Elevation of Twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosis

15 Jun 2015

Abstract excerpt

BACKGROUND/PURPOSE: Oral submucous fibrosis (OSF), a chronic progressive scarring disease, has been considered as a precancerous condition of oral mucosa. In this study, we investigated the functional role of Twist, an epithelial-mesenchymal transition (EMT) transcriptional factor, in myofibroblastic differentiation activity of OSF. METHODS: Arecoline, a major areca nut alkaloid, was used to explore whether...

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Identifiers

PMID: 26088962
DOI: 10.1016/j.jfma.2015.05.009

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