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Article

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.

eLife - 14 Jan 2020

Bowie Emily, Goetz Sarah C

Abstract excerpt

Primary cilia are vital signaling organelles that extend from most types of cells, including neurons and glia. These structures are essential for development of many tissues and organs; however, their function in adult tissues, particularly neurons in the brain, remains largely unknown. Tau tubulin kinase 2 (TTBK2) is a critical regulator of ciliogenesis, and is also mutated in a hereditary neurodegenerative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31934864
DOI: 10.7554/eLife.51166
PMCID: PMC7028366

Genes

TTBK2
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.PMID 31934864Read ↗

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neuronsSemantic proximity Read ↗

Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.Semantic proximity Read ↗

Spinocerebellar ataxia type 11-associated alleles of <i>Ttbk2</i> dominantly interfere with ciliogenesis and cilium stabilitySemantic proximity Read ↗

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Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis.Semantic proximity Read ↗

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