Article

Glycolysis-stratified coordination of fatty acid and glutamine metabolism in pancreatic ductal adenocarcinoma

2025-09-17

Abstract excerpt

<h4>Background</h4> Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and characterized by profound metabolic rewiring. Prior work, including evidence that ketogenic diet (KD) exposure can increase tricarboxylic acid (TCA) activity and glutamine (GLN) dependence and sensitize PDAC to GLN-targeting strategies, suggests that fatty acid (FA) availability may modulate GLN utilization. However, it remains uncle...

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Literature Corpus work: 57fc8939-3938-5e6c-b9d0-17dc9cc5ee10
DOI: 10.1101/2025.09.14.676164

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