Article

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

1993-10-01

Abstract excerpt

We have isolated cDNAs for four human genes (DPDE1 through DPDE4) closely related to the dnc learning and memory locus of Drosophila melanogaster. The deduced amino acid sequences of the Drosophila and human proteins have considerable homology, extending beyond the putative catalytic region to include two novel, highly conserved, upstream conserved regions (UCR1 and UCR2). The upstream conserved regions are locate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57f0ac6e-5289-51e9-8f63-bfbdf03f4d1d
DOI: 10.1128/mcb.13.10.6558

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.DOI 10.1128/mcb.13.10.6558Read

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant DrugsSemantic proximity Read

The human phosphodiesterase PDE10A geneSemantic proximity Read

Cyclic nucleotide phosphodiesterases in <i>Drosophila melanogaster</i>Semantic proximity Read

Conditional rescue of the dunce learning/memory and female fertility defects with Drosophila or rat transgenes.Semantic proximity Read

Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells.Semantic proximity Read

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2Semantic proximity Read

The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil.Semantic proximity Read

A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain.Semantic proximity Read

Progress in understanding the Drosophila dnc locus.Semantic proximity Read

Isolation and characterization of PDE10A, a novel human 3′, 5′-cyclic nucleotide phosphodiesteraseSemantic proximity Read

A neuropeptide gene defined by the Drosophila memory mutant amnesiac.Semantic proximity Read

Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce.Semantic proximity Read