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Article

Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce.

Cell reports - 10 Jan 2017

Ruppert Manuela, Franz Mirjam, Saratsis Anastasios, Velo Escarcena Laura, Hendrich Oliver, Gooi Li Ming, Schwenkert Isabell, Klebes Ansgar, Scholz Henrike

Abstract excerpt

The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster. To understand how cellular stress changes neuronal function, we analyzed Hangover function on a cellular and neuronal level. We provide evidence that Hangover acts as a nuclear RNA binding protein and we identified the phosphodiesterase 4d ortholog dunce as a target RNA. We generated a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28076795
DOI: 10.1016/j.celrep.2016.12.048

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