Article

Monocyte production of C1q potentiates CD8 <sup>+</sup> T cell effector function following respiratory viral infection

2023-06-06

Abstract excerpt

<h4>Summary</h4> Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus (HMPV), we identified recruitment of a C1q-producing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8 + T cell function. Production of C1q by a myeloid lineage was sufficient to enhance...

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Literature Corpus work: 57b47d34-94ed-5202-877a-963b4efa39d8
DOI: 10.1101/2023.06.04.543430

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