Article

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

2020-04-24

Abstract excerpt

Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The Escherichia coli GntR-type transcriptional repressor, NanR, regulates sialic acid metabolism, but the mechanism is unclear. Here, we demonstrate that three NanR dimers bind a (GGTATA) 3 -repeat opera...

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Literature Corpus work: 579887d0-badc-50d4-a337-1ad96badba0d
DOI: 10.1101/2020.04.22.056440

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