Article
Potential translational targets revealed by linking mouse grooming behavioral phenotypes to gene expression using public databases.
Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2013
Roth Andrew, Kyzar Evan J, Cachat Jonathan, Stewart Adam Michael, Green Jeremy, Gaikwad Siddharth, O'Leary Timothy P, Tabakoff Boris, Brown Richard E, Kalueff Allan V
Abstract excerpt
Rodent self-grooming is an important, evolutionarily conserved behavior, highly sensitive to pharmacological and genetic manipulations. Mice with aberrant grooming phenotypes are currently used to model various human disorders. Therefore, it is critical to understand the biology of grooming behavior, and to assess its translational validity to humans. The present in-silico study used publicly available gene...
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