Article
Identification of a D-glycero-D-manno-heptosyltransferase gene from Helicobacter pylori.
Journal of bacteriology - 1 Aug 2005
Hiratsuka Koji, Logan Susan M, Conlan J Wayne, Chandan Vandana, Aubry Annie, Smirnova Natalia, Ulrichsen Heather, Chan Kenneth H N, Griffith Douglas W, Harrison Blair A, Li Jianjun, Altman Eleonora
Abstract excerpt
We have identified a Helicobacter pylori d-glycero-d-manno-heptosyltransferase gene, HP0479, which is involved in the biosynthesis of the outer core region of H. pylori lipopolysaccharide (LPS). Insertional inactivation of HP0479 resulted in formation of a truncated LPS molecule lacking an alpha-...
Topics
- Animals
- Carbohydrate Sequence
- Cloning, Molecular
- Genes, Bacterial
- Glycosyltransferases
- Helicobacter pylori
- Lipopolysaccharides
- Mice
- Molecular Sequence Data
- Mutation
- Sequence Homology
- Stomach
- Virulence