Article

Transmembrane 163 (TMEM163) protein effluxes zinc

2019-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Recent investigations of rodent Tmem163 suggest that it binds to and transports zinc as a dimer, and that alanine mutagenesis of its two species-conserved aspartate (D123A/D127A) residues proposed to bind zinc perturbs protein function. Direct corroboration, however, is lacking whether it is an influx or efflux transporter in cells. We hypothesized that human TMEM163 is a zinc effluxer based on...

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Literature Corpus work: 5748ca12-fec3-5840-a45d-22889ccd99c2
DOI: 10.1101/692525

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