Article

Proteomic analysis of human iPSC derived neural stem cells and motor neurons identifies proteasome structural alterations.

2023-10-09

Abstract excerpt

<h4>Background: </h4> Proteins targeted by the Ubiquitin Proteasome System (UPS) are identified for degradation by the proteasome, which has been implicated in the development of neuro-degenerative diseases. Major histocompatibility complex (MHC) molecules present peptides broken down by the proteasome and are involved in neuronal plasticity, regulating synapse number and axon regeneration in the central or periph...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5686d436-a7a6-5dbb-853e-bf2548cdfe93
DOI: 10.20944/preprints202310.0391.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteomic analysis of human iPSC derived neural stem cells and motor neurons identifies proteasome structural alterations.DOI 10.20944/preprints202310.0391.v1Read

The Ubiquitin Proteasome System in Neuromuscular Disorders: Moving Beyond MovementSemantic proximity Read

Proteasome impairment in neural cells derived from HMSN-P patient iPSCs.Semantic proximity Read

Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer’s diseaseSemantic proximity Read

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neuronsSemantic proximity Read

Deciphering the protein dynamics and molecular determinants of iPSC-derived neuronsSemantic proximity Read

The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disordersSemantic proximity Read

Neural Stem Cells (NSCs) and ProteomicsSemantic proximity Read

Temporal dynamics of proteome and phosphorproteome during neuronal differentiation in the reference KOLF2.1J iPSC lineSemantic proximity Read

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neuronsSemantic proximity Read

A Bioinformatic Investigation of Proteasome And Autophagy Expression in The Central Nervous SystemSemantic proximity Read

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.Semantic proximity Read

Global Transcriptome Profile of the Developmental Principles of in Vitro iPSC-to-Motor Neuron DifferentiationSemantic proximity Read