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Gene-modified NK Cells Expressing CD64 and Pre-loaded with HIV-specific BNAbs Target Autologous HIV-1 Infected CD4 <sup>+</sup> T Cells by ADCC

2024-06-25

Abstract excerpt

NK cells can efficiently mediate antibody-dependent cellular cytotoxicity (ADCC) of antibody coated target cells via the low-affinity Fc-receptor, CD16, but cannot retain antibodies over time. To increase antibody retention and facilitate targeted ADCC, we genetically modified human NK cells with the high-affinity Fc receptor, CD64, so that we could pre-load them with HIV-specific BNAbs and enhance their capacity...

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Literature Corpus work
5666c270-53c3-536d-ab2c-e290d07b6cec
DOI
10.1101/2024.06.20.599937
Open publication

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Gene-modified NK Cells Expressing CD64 and Pre-loaded with HIV-specific BNAbs Target Autologous HIV-1 Infected CD4 <sup>+</sup> T Cells by ADCCDOI 10.1101/2024.06.20.599937
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