Article

A novel STK4 mutation in two siblings with CD4 lymphopenia, recurrent infections and warts: a case report and review of the literature

2026-08-03

Abstract excerpt

Serine-threonine kinase 4 ( STK4 ) deficiency is a rare primary immunodeficiency disorder characterized by progressive T-cell lymphopenia, recurrent infections, cutaneous warts, abscesses, autoimmunity, and cardiac manifestations. This condition is associated with impaired immune surveillance, predisposing patients to severe infections and immune dysregulation. Herein, we report a consanguineous Persian family wit...

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Literature Corpus work: 23eb7713-5472-53d2-83ab-9540518296d5
DOI: 10.1186/s13256-026-06435-8

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