Article
Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity.
PLoS neglected tropical diseases - 1 Jul 2017
Doyle Stephen R, Bourguinat Catherine, Nana-Djeunga Hugues C, Kengne-Ouafo Jonas A, Pion Sébastien D S, Bopda Jean, Kamgno Joseph, Wanji Samuel, Che Hua, Kuesel Annette C, Walker Martin, Basáñez Maria-Gloria, Boakye Daniel A, Osei-Atweneboana Mike Y, Boussinesq Michel, Prichard Roger K, Grant Warwick N
Abstract excerpt
BACKGROUND: Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvulus populations from Cameroon and Ghana-exposed to more than a decade of regular ivermectin treatment-have raised...
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